「中东呼吸综合症」新冠靶点新视角二: 跨膜蛋白酶ADAM17和TMPRSS2( 三 )


7. Ariane Paoloni-Giacobino, Haiming Chen, Manuel C. Peitsch et al. Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR Domains and maps to 21q22.3. Genomics. 1997.
8. Ilona Glowacka, Stephanie Bertram, Marcel A. Muller et al. Evidence that TMPRSS2 activates the severe anute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. Journal of Virology. 2011.
9. Markku H. Vaarala, Katja S. Porwari et al. Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. Journal of pathology. 2001.
10. Zhongshan Cheng, Jie Zhou, Kelvin Kai-Wang To et al. Identification of TMPRSS2 as a susceptibility gene for severe 2009 pandemic A(H1N1) infuenza and A(H7N9) influenza. Journal of Investigative Dermatology. 2015.
11. Manon Laporte and Lieve Naesens. Airway proteases: an emerging drug target for influenza and other respiratory virus infections. Current opinion in virology. 2017.
12. Kazuya Shirato, Mlyuki Kawase, Shutoku Matsuyama. Middle east respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2. JVI. 2013.
13. Stephanie Bertram, Ronald Dijkman, Matthias Habjan et al. TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium. JVI. 2013.
14. Stefanie Glerer, Stephanie Bertram, Granziska Kaup et al. The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies. JVI. 2013.
15. Shutoku Matsuyama, Noriyo Nagata, Kazuya Shirato et al. Efficient antivation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2. Journal of virology. 2010.
16. Eva Bottcher, Tatyana Matrosovich, Michaela Beyerle et al, Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. Journal of virology. 2006.
17. Naoko lwata-Yoshikawa, Tadashi Okamura, Yukiko Shimizu et al. TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection. Journal of virology. 2019.
18. Adeline Heurich, Heike Hofmann-Winkler, Stefanie Gierer et al. TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. JVI. 2014.
19. Inoue, Y., Tanaka, N., Tanaka, Y., Inoue, S., Morita, K., Zhuang, M., Hattori, T., & Sugamura, K. Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted. J Virol. 2007.
20. Wang, H., Yang, P., Liu, K., Guo, F., Zhang, Y., Zhang, G., & Jiang, C. SARS coronavirus entry into host cells through a novel clathrin- and caveolaeindependent endocytic pathway. Cell Res. 2008.